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- W2348092800 abstract "Objective:To investigate the costimulating effect of CD3mAb and leukocyte function associated antigen 1 monoclonal antibody (LFA 1mAb) on proliferation and IL 2 production of peripheral blood mononuclear cells (PBMC) in patients with lupus nephritis (LN). Methodology:Twenty nine patients with LN (14 cases in the active stage and 15 in the inactive stage of LN) were selected for this study,and 12 healthy persons were served as controls.PBMC were treated with CD3mAb or/and FLA 1mAb and Wortmannin (WT).one of specific inhibitor of 1 phosphatidylinositol 3 kinase (PI3 K) for 96 hours.PBMC were obtained by Ficoll Density Gradient Centrifugation,and cell proliferation was detected by 3H TdR incorporation,and ELISA was used to measure IL 2 in supernatant of cultural PBMC. Results:After PBMC were cultured for 96h,in conspontaneous condition,there were no significance in 3H TdR incorporation and IL 2 contents of cultured PBMC among active LN (both of P 0 05),inactive (both of P 0 05) and controls(both of P 0 05),When PBMC from controls,active and inactive LN cultured with CD3mAb alone,compared with conspontaneous condition,the 3H TdR incorporation and contents of IL 2 in PBMC were increased in active LN (both of P 0 05) and inactive LN (both of P 0 05),but were not in healthy controls (both of P 0 05).Compared with CD3mAb alone,costimulation of CD3mAb and LFA 1mAbs enhanced markedly the 3H TdR incorporation and contents of IL 2 in PBMC in active LN (both of P 0 01,respectively),inactive LN (both of P 0 05,respectively),especially in active LN.WT markedly inhibited the contents of IL 2 and 3H TdR incorporation induced by LFA 1 costimulation in PBMC in LN (both of P 0 01,respectively). Conclusion:CD3 and LFA 1 has a costimulating effect on PBMC in LN,which can involve in abnormal activation of T and B cell.Wortmannin can inhibted the costimulation induced by CD3mAb and LFA 1mAb in PBMC in patients with LN." @default.
- W2348092800 created "2016-06-24" @default.
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- W2348092800 date "2002-01-01" @default.
- W2348092800 modified "2023-09-25" @default.
- W2348092800 title "Costimulation of CD3mAb and LFA-1mAb on peripheral blood mononuclear cell in vitro in patients lupus nephritis" @default.
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