Matches in SemOpenAlex for { <https://semopenalex.org/work/W2348098083> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2348098083 abstract "Objective To investigate the effects of benazepril on expressions of matrix metallopro teinase-2, tissue inhibitor of metalloproteinase-2 and collagen IV (C-IV) in the kidney of diabetic rats. Methods Forty Sprague -Damly rats were randomly divided into three groups: the control group (C group), diabetes mellitus group (DM group) and diabetic group treated with benazepril (10mg/kg)(DB group). Eight weeks later, expression of MMP-2, TIMP-2 and C-IV in the kidney tissure was determined by immunohistochemistry method (SP)and RT-PCR. Results Compared with C group, expressions of protein and mRNA MMP-2 significantly reduced in the glomeruli,while expressions TIMP-2 and C-IV were increased in the DM group (P0.01). Meanwhile, the pathologic changes of the glomeruli were serious in DM group. The abnormal expressions of these proteins, mRNA and pathologic changes were dramatically improved in diabetic rats by benazepril treatment (P0.01). Conclusion Benazepril can exert protective effects on diabetic nephropathy, partly through upregulating MMP-2 and decreasing TIMP-2, C-IV accumulation in renal cortex." @default.
- W2348098083 created "2016-06-24" @default.
- W2348098083 creator A5007013151 @default.
- W2348098083 date "2009-01-01" @default.
- W2348098083 modified "2023-09-27" @default.
- W2348098083 title "Effects of Benazepril on Expression of Matrix Metalloproteinase-2,Tissue Inhibitor of Metalloproteinase-2 and Collagen IV in Renal Cortex of Diabetic Rats" @default.
- W2348098083 hasPublicationYear "2009" @default.
- W2348098083 type Work @default.
- W2348098083 sameAs 2348098083 @default.
- W2348098083 citedByCount "0" @default.
- W2348098083 crossrefType "journal-article" @default.
- W2348098083 hasAuthorship W2348098083A5007013151 @default.
- W2348098083 hasConcept C104317684 @default.
- W2348098083 hasConcept C105580179 @default.
- W2348098083 hasConcept C109523444 @default.
- W2348098083 hasConcept C126322002 @default.
- W2348098083 hasConcept C134018914 @default.
- W2348098083 hasConcept C185592680 @default.
- W2348098083 hasConcept C204232928 @default.
- W2348098083 hasConcept C2775965246 @default.
- W2348098083 hasConcept C2777363265 @default.
- W2348098083 hasConcept C2778577996 @default.
- W2348098083 hasConcept C2779922275 @default.
- W2348098083 hasConcept C2780091579 @default.
- W2348098083 hasConcept C2991819120 @default.
- W2348098083 hasConcept C55493867 @default.
- W2348098083 hasConcept C555293320 @default.
- W2348098083 hasConcept C71924100 @default.
- W2348098083 hasConcept C84393581 @default.
- W2348098083 hasConceptScore W2348098083C104317684 @default.
- W2348098083 hasConceptScore W2348098083C105580179 @default.
- W2348098083 hasConceptScore W2348098083C109523444 @default.
- W2348098083 hasConceptScore W2348098083C126322002 @default.
- W2348098083 hasConceptScore W2348098083C134018914 @default.
- W2348098083 hasConceptScore W2348098083C185592680 @default.
- W2348098083 hasConceptScore W2348098083C204232928 @default.
- W2348098083 hasConceptScore W2348098083C2775965246 @default.
- W2348098083 hasConceptScore W2348098083C2777363265 @default.
- W2348098083 hasConceptScore W2348098083C2778577996 @default.
- W2348098083 hasConceptScore W2348098083C2779922275 @default.
- W2348098083 hasConceptScore W2348098083C2780091579 @default.
- W2348098083 hasConceptScore W2348098083C2991819120 @default.
- W2348098083 hasConceptScore W2348098083C55493867 @default.
- W2348098083 hasConceptScore W2348098083C555293320 @default.
- W2348098083 hasConceptScore W2348098083C71924100 @default.
- W2348098083 hasConceptScore W2348098083C84393581 @default.
- W2348098083 hasOpenAccess W2348098083 @default.
- W2348098083 hasRelatedWork W2349471982 @default.
- W2348098083 hasRelatedWork W2354815786 @default.
- W2348098083 hasRelatedWork W2361448860 @default.
- W2348098083 hasRelatedWork W2363884231 @default.
- W2348098083 hasRelatedWork W2364855899 @default.
- W2348098083 hasRelatedWork W2365959888 @default.
- W2348098083 hasRelatedWork W2366958510 @default.
- W2348098083 hasRelatedWork W2368101506 @default.
- W2348098083 hasRelatedWork W2368186345 @default.
- W2348098083 hasRelatedWork W2372631785 @default.
- W2348098083 hasRelatedWork W2373183428 @default.
- W2348098083 hasRelatedWork W2376982193 @default.
- W2348098083 hasRelatedWork W2381820246 @default.
- W2348098083 hasRelatedWork W2381860350 @default.
- W2348098083 hasRelatedWork W2390448876 @default.
- W2348098083 hasRelatedWork W2393410415 @default.
- W2348098083 hasRelatedWork W2398113239 @default.
- W2348098083 hasRelatedWork W2403107464 @default.
- W2348098083 hasRelatedWork W285475215 @default.
- W2348098083 hasRelatedWork W61728488 @default.
- W2348098083 isParatext "false" @default.
- W2348098083 isRetracted "false" @default.
- W2348098083 magId "2348098083" @default.
- W2348098083 workType "article" @default.