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- W2348110273 abstract "OBJECTIVE:To establish the method for the simultaneous determination of ginkgolides A,B in plasma.METHODS:Sample pre-treatment consisted of a liquid-liquid extraction and the content of samples was determined by HPLC.The determination was performed on ZORBAX XDB-C18 column with methanol-0.1% formic acid(60:40)as mobile phase at flow rate of 0.3 mL·min-1.The injection volume was 20 μL.A tandem mass spectrometric detection was conducted using multiple reaction monitoring(MRM) under positive ionization mode with a Electrospray ionization(ESI) interface.RESULTS:The intra-day and inter-day variance coefficient of established method were 10.0%.The accuracy was within ±6%.The limit of quantitation of ginkgolide A,B was 2 μg·L-1 The linear range of ginkgolide A,B was 2~500 μg·L-1.CONCLUSION:Established method is simple,accurate and stable,and it can be used as the basis for the content determination of ginkgolides A,B in plasma." @default.
- W2348110273 created "2016-06-24" @default.
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- W2348110273 date "2011-01-01" @default.
- W2348110273 modified "2023-09-22" @default.
- W2348110273 title "Simultaneous Determination of Ginkgolides A,B of Shuxuening Injection in Plasma by HPLC-MS" @default.
- W2348110273 hasPublicationYear "2011" @default.
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