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- W2348131946 abstract "Objective To observe the effect and mechanism of cyclosporin A(CsA) gutta on keratoconjunctivitis sicca. Methods To induce the animal model of keratoconjunctivitis sicca,Pertussis vaccine + CFA + antigen of the homologous mouse conjunctiva were used for injection.Then keratoconjunctivitis sicca was treated with 0.05% or 1% of CsA gutta and(0.025%) of dexamethasone gutta(0.9% sodium chloride solution as the control),and the breaking up time(BUT) of lacrimal membrane,the amount of lacrimal secretion before and after the therapy were observed.The reablement of the conjunctiva goblet cell and the degree of lymphocyte infiltration were observed with pathological sections,and the change in AQP3,with immunohistochemical method. Results Before and after treatment with CsA gutta,the amount of lacrimal secretion,BUT and the expression of AQP3 showed remarkable change,the cells that were depauperated had some recovery after being treated by(0.05%) and 1% of CsA gutta,but 1% of CsA had prominent irritation to eye surface,and dexamethasone had no prominent therapeutic effect. Conclusion CsA gutta has marked therapeutic effect on keratoconjunctivitis sicca by inhibiting T lymphocyte,increasing the amount of goblet cell and AQP3 in conjunctiva." @default.
- W2348131946 created "2016-06-24" @default.
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- W2348131946 date "2006-01-01" @default.
- W2348131946 modified "2023-09-23" @default.
- W2348131946 title "The Mechanism of Cyclosporina A Gutta in the Treatment of Keratoconjunctivitis Sicca" @default.
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