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- W2348131988 abstract "Objective To investigate the configuration and function of retinal damage in high intraocular pressure of rabbits. Methods 20 rabbits(40 eyes) were divided into ocular hyp ertension(OHT,20 eyes) and control groups(20 eyes) randomly.In OHT group 0.2 ml of carbomer was injected into one anterior chamber randomly of each rabbi t to make high IOP model,and paracentesis was performed without any injection c onsisted of control group.IOP was observed at the same time everyday,if IOP w as less than 30 mmHg which lasted two days,carbomer had to be given again.Cup /disc(C/D) ratio of optic disc and F-ERG were obtained before the operation,a fter the operation 7 th,14 th,21th,28 th-days separately. Results Average of IOP was above 30 mmHg in OHT group.T here was difference between OHT and control groups in IOP(P0.01).Ther e was no difference in C/D ratio between two groups before the operation and pos t-operation 1 week(P0.05),but 14 days later there was difference(P 0.05).7 days post-operation, the total amplitude of b and Ops wave in the OHT were lower than those of contr ol group(P0.05).21 days later there was difference in a wave amplitud e(P 0.05).7 days later,the most obvious change was the thickness of the ganglio n cells layer in OHT group and the lost of RGCs(29.41%,P0.05)and Nf( 52.43%,P0.001),there were differences between the two groups(P0.05).Differences became more obvious with high intraocular pressure time longer. Conclusions Change of amplitude of b and Ops wave is an i mportant diadynamic criteria to glaucoma." @default.
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- W2348131988 date "2012-01-01" @default.
- W2348131988 modified "2023-09-25" @default.
- W2348131988 title "The configuration and function of retinal damage during intraocular hypertension in rabbits" @default.
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