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- W2348137483 abstract "Objective: To observe emodin atherosclerosis(AS) model of serum blood fat in mice and the effect of inflammatory factor,and to evaluate emodin in lipid-lowering and resistance of the role of atherosclerosis.Methods:Sixty males apoE-/-mice fed after one week were randomly divided into the model group(n = 15) and the emodin group(n = 45),and then the emodin group were randomly divided into the high dose group(1200 mg/kg·d),the dosage group(900 mg/kg·d.) and the low dose group(600 mg/kg·d),with 15 mice in every group.The normal control group were given ordinary particles fodder,the model group were given high cholesterol feed(0.25% cholesterol + 15% fat),and the emodin group were given high cholesterol + emodin.All the mice were put to death after 12 weeks feeding.All the animals were weighed and blood fat and serum inflammatory factor were detected before being put to death.Results: The weight of emodin mice model was significantly higher than that of the high dose group(P0.05) at 12 weekend,and the emodin treatment group had significantly lower level of TC(P0.05 ～ 0.01),and the effect of medicines was obviously dose dependent(P 0.05).The hs CRP level in all the three emodin treatment groups had significantly lower Fib concentration(P0.05 ～ 0.01),and those of low dose group and dosage group were significantly higher than that of the high dose group.Conclusion: Emodin has an overall role of intervention with the occurrence of AS." @default.
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- W2348137483 date "2012-01-01" @default.
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- W2348137483 title "Study of emodin in mice atherosclerosis intervention model" @default.
- W2348137483 hasPublicationYear "2012" @default.
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