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- W2348141507 abstract "OBJECTIVE: To confirm the feasibility of target-controlled infusion of midazolam on conscious sedation for patients undergoing combined spinalepidural anesthesia and the needed target-controlled blood concentration.METHODS: Sixty patients undergoing combined spinal-epidural anesthesia were subjected to target-controlled infusion of midazolam.The level of sedation of midazolam was evaluated applying OAA/S score and bispectral index(BIS).The correlation between target-controlled blood concentration(Cp) and BIS was determined.The Cp,BIS,MAP,HR and SpO2 at different OAA/S were observed. RESULTS: When OAA/S score was 3,the required target-controlled blood concentration of midazolam was(122.8± 20.8) ng· mL-1 in midazolam sedation patients.There was a good correction between BIS and Cp,and BIS=— 3.28Cp+ 355.22(r=— 0.862 5,P0.01).CONCLUSION: Target-controlled infusion of midazolam on conscious sedation for patients undergoing combined spinal-epidural anesthesia were satisfactory in controllability and level of sedation,and which did no impact on hemodynamics and respiratory function of patients." @default.
- W2348141507 created "2016-06-24" @default.
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- W2348141507 date "2007-01-01" @default.
- W2348141507 modified "2023-09-26" @default.
- W2348141507 title "Target-controlled Infusion of Midazolam on Conscious Sedation for Patients Undergoing Combined Spinal-epidural Anesthesia" @default.
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