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- W2348148967 abstract "Objective To study the combined effects of nonylphenol(NP)and bisphenol A(BPA)on fertility of mice and their combined toxicity.Methods Four hundred mature KM mice(22~24 g in body weigth,clean animal)were divided into differnet groups(control group:24,60 and 120 mg/kg NP;48,120 and 240 mg/kg BPA;12 mg/kg NP+24 mg/kg BPA,30 mg/kg NP+60 mg/kg BPA,and60 mg/kg NP+120 mg/kg BPA).Fertility tests were performed by the procedure recommended by FDA of the US.Combined effects of NP and BPA on fertility were assessed by Jin zheng-jun method.Results NP and BPA showed synergetic effects on sperm vitality rate,mating rate,implantation rate at low and medium doses,and antagonistic at high dose.The combined effect on pregnancy rate in low dose group was synergism,but effects in medium and high dose groups were antagonism.NP and BPA showed synergetic on normal rate of sperm morphological in all mixed groups;however,it was antagonistic on fertility,live fetuses rate,and dead fetuses rate.Conclusions Combined effects of NP and BPA on fertility in mice were synergetic in low dose group,synergetic and antagonistic in medium dose group,and antagonistic in high dose group." @default.
- W2348148967 created "2016-06-24" @default.
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- W2348148967 date "2007-01-01" @default.
- W2348148967 modified "2023-09-23" @default.
- W2348148967 title "Combined Effects of Nonylphenol and Bisphenol A on Fertility of Mice" @default.
- W2348148967 hasPublicationYear "2007" @default.
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