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- W2348152251 abstract "ANX Ⅰ has been convincingly demonstrated to mediate the anti inflammatory effects of glucocorticoids in a variety of models of inflammation in vivo and in vitro.It was thought to be one of the ‘second messengers' of glucocorticoids in the actions of anti inflamma_ tory.However,the correlation between ANX Ⅰ and primary lung cancer remains unknown.In this study,the expression distribution of ANXⅠwas examined in 60 primary lung cancer specimens by immunohistochemistry and in immortal,transformation and malignant transformation cell lines by comparative proteomics.The results showed that expression distribution of ANXⅠpresented a significant relationship with histological subtype of lung cancer (P0.05).Low expression of ANXⅠexisted in immortal cells(989.13±59.34),moderate expression in transformation cells(1520.30±91.22),high expression in malignant transformation cells (2508.00±150.47,P0.01).[Conclusions]These indicate that high expression of ANXⅠmay be involved in initiation or promotion stage of squamous lung carcinoma and play a critical role in malignant transformation of human bronchial epithelial cell as well." @default.
- W2348152251 created "2016-06-24" @default.
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- W2348152251 date "2001-01-01" @default.
- W2348152251 modified "2023-09-25" @default.
- W2348152251 title "The Profile of ANX I Expression in Lung Cancer and BEP2D Transformation Cell Model" @default.
- W2348152251 hasPublicationYear "2001" @default.
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