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- W2348164628 abstract "[Objective] To investigate the inhibitory effect of a small peptide from Agkistrodon acutus venom on the growth of human gastric carcinoma SGC-7901 cell line and its mechanism. [Methods] The SGC-7901 cells were treated with the small peptide at different concentrations. The proliferation of SGC-7901 cells was assayed with MTT colorimetric method. The histological and ultrastructural changes of the cells were scored using light and electron microscopy.The apoptosis of SGC-7901 cells induced by the small peptide was studied by fluorescent staining, Crystal violet staining and MTT assay were employed to determine the effect of the small peptide on adhesion of SGC-7901 cells to fibronectin. [Results] Proliferation of SGC-7901 cells was inhibited significantly by a small peptide from Agkistrodon acutus venom in a dosage and time dependant manner. Under electron-microscope and fluorescent microscope some SGC-7901 cells underwent typical apoptosis and morphological changes after 24 hours' incubation with the small peptide. The small peptide could inhibit the adhesion of SGC-7901 cells to fibronectin in a dose-dependent manner. [Conclusion] A small peptide can inhibit proliferation of SGC-7901 cells,which may be related to the mechanism of inducing cellular apoptosis and inhibiting cellular adhesion." @default.
- W2348164628 created "2016-06-24" @default.
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- W2348164628 date "2008-01-01" @default.
- W2348164628 modified "2023-09-23" @default.
- W2348164628 title "Effect of polypeptide from Agkistrodon acutus venom on adhesion and proliferation of human gastric carcinoma SGC-7901 cell line" @default.
- W2348164628 hasPublicationYear "2008" @default.
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