Matches in SemOpenAlex for { <https://semopenalex.org/work/W2348169100> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2348169100 abstract "Objective To investigate the protective effect and possible mechanism of camptothecin in the lipopolysaccharide-induced dopaminergic neurons(DN) injury.Methods After establishing DN and neuron-astrocyte mixed culture systems,the survival rate of DN,expression of tyrosine hydroxylase(TH) mRNA,the levels of tumor necrosis factor-α(TNFα),nitrogen monoxidum(NO),interleukin 6(IL-6) and glial cell line-derived neurotrophic factor(GDNF) were detected in response to different treatments.Results Camptothecin 10 mg/L significantly promoted DN apoptosis in DN culture system(P0.05).Compared with control group,different concentrations of camptothecin increased positive cell population and mRNA expression of TH (P0.05),decreased the levels of NO,TNF-α and IL-6(P0.05),but only camptothecin 10 mg/L enhanced DN apoptosis in neuron-astrocyte mixed culture system(P0.05).Conclusion Camptothecin in a proper concentration can inhibit proinflammatory factors secreted by astrocyte,which in turn protects neuron." @default.
- W2348169100 created "2016-06-24" @default.
- W2348169100 creator A5043684819 @default.
- W2348169100 date "2011-01-01" @default.
- W2348169100 modified "2023-09-23" @default.
- W2348169100 title "The protective effect of camptothecin on inflammation-induced dopaminergic neurons injury" @default.
- W2348169100 hasPublicationYear "2011" @default.
- W2348169100 type Work @default.
- W2348169100 sameAs 2348169100 @default.
- W2348169100 citedByCount "0" @default.
- W2348169100 crossrefType "journal-article" @default.
- W2348169100 hasAuthorship W2348169100A5043684819 @default.
- W2348169100 hasConcept C134018914 @default.
- W2348169100 hasConcept C137183658 @default.
- W2348169100 hasConcept C159167319 @default.
- W2348169100 hasConcept C160539049 @default.
- W2348169100 hasConcept C164027704 @default.
- W2348169100 hasConcept C169760540 @default.
- W2348169100 hasConcept C170493617 @default.
- W2348169100 hasConcept C17991360 @default.
- W2348169100 hasConcept C185592680 @default.
- W2348169100 hasConcept C185856081 @default.
- W2348169100 hasConcept C190283241 @default.
- W2348169100 hasConcept C203014093 @default.
- W2348169100 hasConcept C2776914184 @default.
- W2348169100 hasConcept C2777542381 @default.
- W2348169100 hasConcept C2778794669 @default.
- W2348169100 hasConcept C2779682216 @default.
- W2348169100 hasConcept C513476851 @default.
- W2348169100 hasConcept C529278444 @default.
- W2348169100 hasConcept C55493867 @default.
- W2348169100 hasConcept C86803240 @default.
- W2348169100 hasConcept C98274493 @default.
- W2348169100 hasConceptScore W2348169100C134018914 @default.
- W2348169100 hasConceptScore W2348169100C137183658 @default.
- W2348169100 hasConceptScore W2348169100C159167319 @default.
- W2348169100 hasConceptScore W2348169100C160539049 @default.
- W2348169100 hasConceptScore W2348169100C164027704 @default.
- W2348169100 hasConceptScore W2348169100C169760540 @default.
- W2348169100 hasConceptScore W2348169100C170493617 @default.
- W2348169100 hasConceptScore W2348169100C17991360 @default.
- W2348169100 hasConceptScore W2348169100C185592680 @default.
- W2348169100 hasConceptScore W2348169100C185856081 @default.
- W2348169100 hasConceptScore W2348169100C190283241 @default.
- W2348169100 hasConceptScore W2348169100C203014093 @default.
- W2348169100 hasConceptScore W2348169100C2776914184 @default.
- W2348169100 hasConceptScore W2348169100C2777542381 @default.
- W2348169100 hasConceptScore W2348169100C2778794669 @default.
- W2348169100 hasConceptScore W2348169100C2779682216 @default.
- W2348169100 hasConceptScore W2348169100C513476851 @default.
- W2348169100 hasConceptScore W2348169100C529278444 @default.
- W2348169100 hasConceptScore W2348169100C55493867 @default.
- W2348169100 hasConceptScore W2348169100C86803240 @default.
- W2348169100 hasConceptScore W2348169100C98274493 @default.
- W2348169100 hasLocation W23481691001 @default.
- W2348169100 hasOpenAccess W2348169100 @default.
- W2348169100 hasPrimaryLocation W23481691001 @default.
- W2348169100 hasRelatedWork W1570444420 @default.
- W2348169100 hasRelatedWork W1863689565 @default.
- W2348169100 hasRelatedWork W2009965519 @default.
- W2348169100 hasRelatedWork W2040483531 @default.
- W2348169100 hasRelatedWork W2050001104 @default.
- W2348169100 hasRelatedWork W2065696410 @default.
- W2348169100 hasRelatedWork W2075664080 @default.
- W2348169100 hasRelatedWork W2091713828 @default.
- W2348169100 hasRelatedWork W2092625934 @default.
- W2348169100 hasRelatedWork W2297819692 @default.
- W2348169100 hasRelatedWork W2376625793 @default.
- W2348169100 hasRelatedWork W2770625956 @default.
- W2348169100 hasRelatedWork W2807756887 @default.
- W2348169100 hasRelatedWork W2887093153 @default.
- W2348169100 hasRelatedWork W2944735145 @default.
- W2348169100 hasRelatedWork W2969546731 @default.
- W2348169100 hasRelatedWork W2973527205 @default.
- W2348169100 hasRelatedWork W2995639486 @default.
- W2348169100 hasRelatedWork W2998676943 @default.
- W2348169100 hasRelatedWork W3032154944 @default.
- W2348169100 isParatext "false" @default.
- W2348169100 isRetracted "false" @default.
- W2348169100 magId "2348169100" @default.
- W2348169100 workType "article" @default.