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- W2348193048 abstract "Objective To investigate the diagnosis of the disorders with Parkinson-like symptoms(PLS).Methods The clinical data of 78 patients with PLS admitted in our hospital during 2008-01 to 2010-12 were analyzed retrospectively,including medical history,physical examinations,clinical manifestations,blood biochemistry,parathyroxin,ceruloplasmin,levodopa(L-dopa) test,brain CT scan and MR imaging.The final clinical diagnosis was made according to the diagnostic criteria of PLS related disorders.Results For clinical manifestations,among the 78 patients,there were 74 cases with hypermyotonia,67 cases with tremor,65 cases with bradykinesia,56 cases with abnormal postural reflex,52 cases with abnormal gait,5 cases with orthostatic hypotension,4 cases with vertical gaze palsy,2 cases with positive K-F corneal ring,2 cases with visual hallucination,and 1 case with unilateral limb ignorance due to apraxia.The blood biochemistry tests showed abnormal liver function in 5 cases,reduced serum ceruloplasmin level in 2 cases and reduced serum parathyroxin level in 1 case.The CT scan revealed low density in basal ganglia in 59 cases,cerebral atrophy in 35 cases,encephalomalacia in 10 cases,and calcifications existing in the basal ganglia and cerebellar hemisphere in 2 cases.The MR imaging showed abnormal signals in the basal ganglia,the brain stem and the brain white matter in 65 cases,atrophy in pons and cerebellum in 5 cases,putamen fissure sign in 4 cases,cross sign in pons in 3 cases,cerebral hummingbirds sign in 1 case,high intensity in pallidum on T2 in 2 cases.31 cases showed poor response to L-dopa treatment.There were 36 cases diagnosed clinically as PD,28 cases diagnosed as parkinsonian syndrome(PS),4 cases diagnosed as multiple system atrophy(MSA),4 cases diagnosed as progressive supranuclear palsy(PSP),2 cases diagnosed as Lewy body(DLB),2 cases diagnosed as Wilson disease(WD),1 case diagnosed as basal ganglia calcification(BGC)and 1 case diagnosed as corticobasal degeneration(CBD).Among those 28 cases diagnosed as PS,16 cases were induced by cerebral vascular diseases,5 cases by poisoning(3 cases by carbon monoxide and the other 2 cases by pesticide),3 cases by brain injury,2 cases by encephalitis,and 2 cases by drugs.Conclusions Reliable medical history collection,characteristic signs finding,special radiographic changes,serum ceruloplasmin and parathyroxin abnormalities,and poor response to L-dopa treatment contribute greatly to the diagnosis and differential diagnosis of PLS-related disorders." @default.
- W2348193048 created "2016-06-24" @default.
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- W2348193048 date "2012-01-01" @default.
- W2348193048 modified "2023-09-23" @default.
- W2348193048 title "Study on the diagnosis of disorders with Parkinson-like symptoms" @default.
- W2348193048 hasPublicationYear "2012" @default.
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