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- W2348193826 abstract "Objective To explore the relationship between microsatellite instability and clinico pathological features in gastric cancer and its clinic significance. Methods Formalin fixed, paraffin embedded tumor specimens and matching normal tissues of 65 cases with gastric carcinoma were retrieved from Ruijin Hospital. DNAs were extracted from tissue sections using phenol chloral isopantyalcohol. DNAs from gastric tumors and paired normal DNAs were amplified by PCR based SSCP (simple strand conformation polymorphism) at five microsatellite loci for microsatellite analysis. Results The tumors were classified as being microsatellite stable (MSS) or having a low frequency of MSI (MSI L, one marker positive ) or a high frequency of MSI (MSI H, two or more markers positive). The results demonstrated MSI L in 11 cases (18.0%), MSI H in 12(19.7%) and MSS in 38(62.3%). There were no significant differences in clinicopathological parameters between MSI L and MSS cases. Significant differences were found between MSI H and MSS or MSI L cases in tumor site, Lauren histological type, lymph node metastasis and tumor stage (P 0.05). MSI H cases showed a predominance of gastric antral cancer, negative lymph node, intestinal type and early stage, but appeared not to be significantly associated with age, gender, and tumor size (P 0.05). Conclusions Gastric cancers of MSI H have different clinicopathological features from those of MSI L and MSS, and the patients with MSI H tumors have a relatively better prognosis than those with MSI L and MSS. The MSI H gastric carcinomas may develop through a distinct pathway." @default.
- W2348193826 created "2016-06-24" @default.
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- W2348193826 date "2004-01-01" @default.
- W2348193826 modified "2023-10-11" @default.
- W2348193826 title "Microsatellite instability in gastric carcinoma and its relationship with clinicopathological features" @default.
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