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- W2348202629 abstract "OBJECTIVE To explore the protective effect of hemin on hypothermic dogs immersed by seawater.METHODS Twelve healthy dogs were devided into two groups: control group and hemin group.To hemin group,hemin(80 μmol/kg,twice a day)were administered through intraperitoneal injection for 2 days before hypothermia model was made.No hemin was used to control group.Then immersed hyperthermia model was made in two groups.Dogs were immersed in cold seawater(12 ±2)℃ until the rectal temperature was decreased to 30℃.Plasma total bilirubin(TB),superoxide dismutase(SOD),aspartate aminotransferase(GOT),lactate dehydrogenase(LDH),creatine kinase(CK),CKMB,interleukin-6(IL-6) and tumor necrosis factor(TNF-α)contents were measured before and after the model was made.All the data were compared between two groups.RESULTS The content of TB and SOD of hemin group was higher than that of control group at 30℃(P0.05).The content of GOT,LDH,CK,CKMB,IL-6 and TNF-α of hemin group was lower than that of control group at 30℃(P0.05).CONCLUSION Hemin could exert protective effect on seawater immersed hypothermic dogs through elevating the serum level of SOD." @default.
- W2348202629 created "2016-06-24" @default.
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- W2348202629 date "2008-01-01" @default.
- W2348202629 modified "2023-09-25" @default.
- W2348202629 title "Protective Effect of Hemin on Hypothermia Dogs" @default.
- W2348202629 hasPublicationYear "2008" @default.
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