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- W2348224814 abstract "AIM: To investigate the differential expression of short-chain acyl-CoA dehydrogenase(SCAD) in cardiac hypertrophy induced by hypertension or exercise training.METHODS: Spontaneously hypertensive rats(SHR) were used as the model of pathological cardiac hypertrophy.The swim-trained rats were used as the model of physiological cardiac hypertrophy.The systolic pressure,cardiac hypertrophy parameters,echocardiogram parameters,free fatty acid in serum and cardiac muscle,and the expression and activity of SCAD in the left ventricle were measured.RESULTS: Compared with the control rats,trained rats developed an athletic heart,of which cardiac function was enhanced,whereas SHR developed hypertensive cardiac hypertrophy,of which cardiac function was deteriorated.Compared with the control rats,the ratios of left ventricular weight to body weight were both increased in trained rats and SHR,showing that the degrees of cardiac hypertrophy were similar in the 2 models.Compared with the control rats,the decrease of free fatty acid both in serum and myocardium indicated that the fatty acid utilization was increased in the left ventricle of trained rats.Meanwhile,the expression and activity of SCAD in the left ventricle of trained rats were increased.However,free fatty acid both in serum and myocardium were increased,indicating that the fatty acid utilization was decreased in the left ventricle of SHR.Furthermore,SHR had the decreased expression and activity of SCAD in the left ventricle.CONCLUSION: The changes of SCAD are different in cardiac hypertrophy induced by hypertension and exercise training,indicating that SCAD may be used as a molecular marker of physiological and pathological cardiac hypertrophy,and a potential therapeutic target of pathological cardiac hypertrophy." @default.
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- W2348224814 date "2012-01-01" @default.
- W2348224814 modified "2023-09-27" @default.
- W2348224814 title "Effect of short-chain acyl-CoA dehydrogenase on cardiac hypertrophy induced by hypertension or exercise training" @default.
- W2348224814 hasPublicationYear "2012" @default.
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