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- W2348239984 abstract "The cytotoxicity of four types of flavonoid monomers, namely chlorogenic acid, ferulic acid, orientin and isoorientin on Chinese hamster ovary(CHO) cells was detected and compared by CCK-8 test and the IC50 values were calculated by Exact Probability. The mitochondrial membrane potential, the production of ATP and the release of cytochrome C were used as the parameters to indicate early cellular damage. The results showed that IC50 of chlorogenic acid, ferulic acid, orientin and isoorientin was 2 726.11, 1 680.28, 1 889.15 and 2 358.56 μmol/L, respectively. At experimental doses of IC50, 1/2 IC50, 1/4 IC50, and 1/8 IC50 for these four monomers, the change of mitochondrial membrane potential was in a dose-dependent manner. Meanwhile, ferulic acid resulted in the largest decease in mitochondrial membrane potential, followed by chlorogenic acid, orientin and isoorientin. The production of ATP was negatively correlated with the dose of flavonoids, which was inhibited by ferulic acid, orientin, chlorogenic acid and isoorientin in this decreasing order. In the case of cytochrome C release, the decreasing order was ferulic acid, orientin, isoorientin and chlorogenic acid. In summary, all the four flavonoids can result in mitochondrial damage at higher or lower levels. Ferulic acid has the highest mitochondrial toxicity, followed by orientin, isoorientin and chlorogenic acid. The change of mitochondrial function may be considered as an index of early cellular damage." @default.
- W2348239984 created "2016-06-24" @default.
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- W2348239984 date "2014-01-01" @default.
- W2348239984 modified "2023-09-24" @default.
- W2348239984 title "Comparison of Early Damage of CHO Cells in the Presence of Different Flavonoid Monomers" @default.
- W2348239984 hasPublicationYear "2014" @default.
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