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• W2348252506 abstract "Objective To explore the effect of occupational stress and gene polymorphisms of β2-AR on hypertension.Methods498 workers from a thermal power plant in Henan province in China,whose accumulative length of service was more than two years were investigated with questionnaire by the method of cluster sampling.The occupational stressors,personalities,buffering factors and occupational strain were measured by using the Job Demand-control Model,the Effort-reward Imbalance Model questionnaires and Occupational Stress Measurement Scale.Some main risk factors for the development of hypertension were investigated,such as heredity,body mass index,high salt diet,alcohol use and lack of physical activity.At the same time,the level of TG,CHO and FPG were detected by the common biochemistry methods.β2-AR genotypes and alleles frequencies at amino acid position 16(β2AR-16:Arg→Gly)and at position 27(β2AR-27:Gln→Glu) of the 116 samples from field epidemiologic survey were detected by PCR-RFLP technology,including 58 males with hypertension and 58 healthy people matched in gender,age,and length of service.The direct and interaction effects of individual demographic variables,occupational stressors,personalities,buffering factors,affection and β2-AR genotypes or alleles on prevalence of hypertension were analyzed by using conditional logistic regression in 1∶1 matched-pairing case-control design.All significant statements were two-tailed.An alpha of 5% was used for all statistical analyses.All analyses were conducted using SPSS 13.0.Results(1)The workers with higher ERI were more likely to suffer hypertension than whom with lower ERI(OR=4.2~5.0).(2)The results of Cox-regression analyses showed that the risk of hypertension for Arg/Gly carriers was 3.21 times as high as that for Arg/Arg carriers.The same pattern of results,but with stronger effects,was found with regard to ERI(OR=4.2).Arg/Gly and Gly/Gly genotypes were associated with hypertension,it was found that the interaction effect of Gly16 allele and ERI on the risk of hypertension.The risk of hypertension for Gln/Glu carriers was 8.0 times as high as that for Gln/Gln carriers.(3)ERI and β2AR-16(Arg→Gly)genotypes had interaction effect on the risk of hypertension(OR=2.6),the interaction effect of β2AR-27(Gln→Glu)genotypes and ERI on the risk of hypertension(OR=2.3)was also found.Gly16 allele and ERI had interaction effect on the risk of hypertension(OR=6.2),there also was interaction effects between Gln 27 allele and ERI on the risk of hypertension(OR=1.6).Job demands,decision latitude or job strain had no direct and interaction effect on the risk of hypertension,meanwhile interaction effect of job strain and β2-AR genotypes on the risk of hypertension has not been found.ConclusionsOccupational stress(ERI)and β2AR-16 genotypes had interaction effect on the risk of hypertension,also did ERI and β2AR-27 genotypes.The effect of β2AR-16 genotypes on the risk of hypertension was larger than that of β2AR-27 genotypes." @default.
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• W2348252506 title "Case Control Study of the Effect of Occupational Stress and Gene Polymorphisms of β_2-AR on Hypertension" @default.
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