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- W2348258751 abstract "Objective:To investigate the correlation of thrombospondin-1(TSP-1) expression and angiogenesis and clinical pathologic factors in breast cancer.Methods:Reverse transcription-polymerase chain reaction(RT-PCR) was used to detect the expression of TSP-1 mRNA in the primary breast cancer tissues and the tissues set apart 5 cm from the tumor.Immunohistochemistry was used to detect the expressions of vascular endothelial growth factor(VEGF), c-erbB2, estrogen receptor(ER), progesterone receptor(PR) and microvessel density(MVD).All data were statistically analyzed.Results:The positive rate of TSP-1 was significantly higher in breast cancer than that in tissues set apart 5 cm from tumor(P 0.05).The expression of TSP-1 was positively correlated with tumor size only(P 0.05).MVD was lower in TSP-1 positive group than that of negative group(P 0.05).Conclusion:The MVD was decreased with up-regulation of TSP-1 expression.Thrombospondin-1 may repress the angiogenesis in breast cancer." @default.
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- W2348258751 date "2009-01-01" @default.
- W2348258751 modified "2023-09-26" @default.
- W2348258751 title "The Expression and Significance of TSP-1 in Breast Cancer" @default.
- W2348258751 hasPublicationYear "2009" @default.
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