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- W2348263304 abstract "[Objective]To investigate the postoperative analgesic effect and inflammatory reaction of tramadol in patients with thoracic surgery.[Method]70 ASAⅠ-Ⅱcases undergone thoracic surgery in our hospital were divided into two groups:the tramadol group and control group(n=35).Two groups both were performed intravenous analgesia. Tramadol group preparation:sufentanil 100μg + tramadol 12 mg/kg + tropisetron 8 mg,control group:sufentanil 0.1 mg + tropisetron 8 mg.Blood samples of the two groups were collected at the end of surgery(T_0) and after 4 h (T_2),8 h(T_3),12 h(T_4),24 h(T_5) operation to test the plasma C-reactive protein(CRP),leukocyte Interleukin -6 (IL-6) and tumor necrosis factor(TNF-) concentration.Visual analogue scales(VAS) were used to evaluate the analgesic effect at 2 h(T_1),4 h(T_2),8 h(T_3),12 h(T_4),24 h(T_5) and the symptom of nausea,vomiting,pruritus and other adverse reactions were also evaluated during 48 hours after operation.[Results]Compared with the control group,at T2-T4 point,the plasma concentrations of IL-6 and CRP in tramadol group were significandy lower,and the difference was statistically significant(P0.01),but there was no statistically significant difference in TNF-αcompared with the control group at each time point(P0.05).Compared with control group,VAS at T2,T3,T4,T5 decreased statistically significandy(P0.05) in tramadol group.[Conclusion]For patients performed thoracic surgery,tramadol can produce good analgesia,reduce perioperative cytokine production,and decrease the release of perioperative stress hormone,which is conducive to postoperative recovery." @default.
- W2348263304 created "2016-06-24" @default.
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- W2348263304 date "2011-01-01" @default.
- W2348263304 modified "2023-09-23" @default.
- W2348263304 title "Influence of tramadol on CRP,TNF-αand IL-6 response and analgesic effect after thoracic surgery" @default.
- W2348263304 hasPublicationYear "2011" @default.
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