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- W2348279829 abstract "Objective To investigate the efficacy and safety of converting cyclosporine(CsA)-based immunosuppressant regimen to tacrolimus(FK506)plus mycophenolate mofetil(MMF)in renal transplantation patients with chronic allograft nephropathy(CAN).Methods Seventy-six cases of CAN were followed up for 6 month,who converted to FK506+MMF from CsA.All cases were divided into chronic rejection(CR)group(n =41)and non-CR group(n =35)according to the pathological results of transplanted kidney.The efficacy and adverse reaction were observed between the two groups.Results In CR group,the renal function were improved in 27 cases(66 %),stable in 9 cases(22 %)and even worse in 5 cases(12 %).In non-CR group,the renal function were improved in 11 cases(31 %),stable in 15 cases(43 %)and even worse in another 9 cases(26 %).The efficacy of immunosuppressant conversion in CR group was more obvious than that in non-CR group(P 0.05).The amount of 24-hour urine protein excretion was reduced compared with the pre-conversion in both CR group and non-CR group.Compared with pre-conversion,the incidence of hypertension and hyperlipidemia were also reduced.There was no case with new onset post transplantation hyperglycaemia as well as with serve infection.Conclusion It suggests that converting to FK506+MMF from CsA-based regimen is safe and effective in treating renal transplantation patients with CAN." @default.
- W2348279829 created "2016-06-24" @default.
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- W2348279829 date "2010-01-01" @default.
- W2348279829 modified "2023-10-15" @default.
- W2348279829 title "Clinical analysis of converting cyclosporine-based immunosuppressant regimen to tacrolimus with mycophenolate mofetil in renal transplantation patients with chronic allograft nephropathy" @default.
- W2348279829 hasPublicationYear "2010" @default.
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