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- W2348287712 abstract "Objectives To investigate the effect of IL-17 on proliferation and secretion of IL-1β in the human mesangial cell line(HMCL) and explore the molecular mechanism. Methods The proliferation of HMCL induced by IL-17 was detected by MTT, the secretion of IL-1β in HMCL was measured by ELISA and the expression of NF-κB was detected by immunocytochemistry. Results IL-17 did not impact HMCL proliferation(P0.05) but dose-and time-dependently promoted the secretion of IL-1β(P0.05). And the expression of NF-κB induced by IL-17 increased comparing to that in the control group(P0.05). Conclusions IL-17 may induce HMCL to secrete IL-1β via NF-κB pathway that results in kidney injury." @default.
- W2348287712 created "2016-06-24" @default.
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- W2348287712 date "2014-01-01" @default.
- W2348287712 modified "2023-09-26" @default.
- W2348287712 title "Influence of IL-17 on mesangial cell and its molecular mechanism" @default.
- W2348287712 hasPublicationYear "2014" @default.
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