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- W2348290858 abstract "OBJECTIVE To investigate the antiarrhythmic effects of pilocarpine in rat and guinea pigs.METHODS Aconi- tine,BaCl_2 and ouabain were used to induce experimental arrhythmic models in Wistar rats and guinea pigs.Effects of pilocar- pine on the occurrence of arrhythmias was observed.RESULTS Pilocarpine substantially depressed the occurrence of arrhyth- mias induced by aconitine.BaCl_2 and ouabain.In the groups of aconitine,the occurrence of arrhythmias were delayed obviously (P0.05)and the survival time after the occurrence of arrhythmias was prolonged obviously(P0.05).In the groups of BaCl_2,the occurrence of arrhythmias was delayed obviously(P0.01)and the persistence of arrhythmias were decreased obvi- ously(P0.01).In the groups of ouabain,the survival time after the occurrence of arrhythmias was also prolonged obviously (P0.05).Meanwhiie,4-DAMP(antagonist of M_3 receptors)could reverse the effects of pilocarpine completely.CONCLUSION Pilocarpine has antiarrhythmic effects on the arrhythmias induced by aconitine,BaCL_2 and ouabain.Pilocarpine plays the anti- arrhythmic roles by activating cardiac M_3 receptors of Wistarrats and guinea pigs." @default.
- W2348290858 created "2016-06-24" @default.
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- W2348290858 date "2008-01-01" @default.
- W2348290858 modified "2023-09-25" @default.
- W2348290858 title "Pharmacological effect of pilocarpin on arrhythmia in nimal studies" @default.
- W2348290858 hasPublicationYear "2008" @default.
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