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- W2348295612 abstract "Objective To investigate whether single nucleotide polymorphism (SNP) of toll like receptor 4 (TLR4) at 3' untranslated region (3' UTR) influences TLR4 protein expression in whole blood culture.Methods A total of 89 samples out of 269 whole blood samples taken from healthy persons were used for cell culture model with/without lipepelysaccharide (LPS) stimulation to measure TLR4 ex- pression level by flow cytometry.SNP of TLR4 gene at 3' UTR 11367G/C and ceding region 896A/G was genotyped with the method of single-tube bi-directional allele specific amplification (SB-ASA) and re- striction fragment length polymorphism (RFLP) technique,respectively.TNF-αproduction in the whole blood culture after stimulated by LPS was also measured.Results Frequency of TLR4 11367 SNP was 17.42%.Genotype frequencies of 11 367 loci were 70.79% (GG),23.60% (GC) and 5.61% (CC), respectively.Among 89 individuals were 63 with homozygate and 21 with heterozygote (GC) for the G al- lele (GG) as well as five with genotype CC.The TLR4 expression in leukocytes was higher in GG ho- mozygate after LPS stimulation compared with individuals with heterozygous GC and homozygous CC (P＜0.05).In addition,the highest values of TNF-αproduction was found in GG homozygate compared with individuals with heterozygous GC and homozygous CC (P＜0.05).No G allele was detected in 896 loci among 269 blood donors.Conclusions SNP of TLR4 gene at 3' UTR exerts significant influence on TLR4 expression,which may be associated with secretion of TNF-αposterior to LPS stimulation." @default.
- W2348295612 created "2016-06-24" @default.
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- W2348295612 date "2006-01-01" @default.
- W2348295612 modified "2023-09-26" @default.
- W2348295612 title "Influence of single nucleotide polymorphism of toll like receptor 4 gene at 3’untranslated region on its protein expression" @default.
- W2348295612 hasPublicationYear "2006" @default.
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