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- W2348309819 abstract "Objective To evaluate bone mineral mass in patients with multiple sclerosis(MS),and the association of glucocorticoid use and ambulation ability with the changes of bone mass.Methods Sixty five patients with MS and 328 age-and sex-matched healthy controls participated in this study in our hospital from 2008 to 2010.The Kurtzke expanded disability status scale(EDSS) was used to evaluate disability and functional capacity.Bone mineral density(BMD) of lumbar spine,femoral neck,and total femur was measured using dual-energy X-ray absorptiometry.Serum calcium,phosphorus,and 25-hydroxy vitamin D 〔25-(OH) D〕levels were assessed.Results The 25-(OH) D level in MS patients was significantly lower than that of the controls(P 0.05),even after the patients were given vitamin D 200 U / d.The MS patients had significantly lower BMD of the lumbar spine,femoral neck and total femur than the controls(P 0.05).The lumbar spine BMD and femoral neck BMD were negatively correlated with MS disease duration(r =-0.45,P = 0.038;r =-0.16,P = 0.017).The 25-(OH) D level was positively correlated with lumbar spine BMD(r = 0.29,P = 0.025).EDSS scores were negatively correlated with BMD(r lumbar spine =-0.17,P = 0.012;r femoral neck =-0.24,P = 0.001;r total femur =-0.31,P = 0.015).There was a negative correlation between cumulative steroid dose and femoral neck BMD(r =-0.30,P = 0.005).Conclusion BMD was significantly lower in MS patients.Glucocorticoid usage and decreased ambulatory status were associated with low BMD in MS patients.These patients should be encouraged to do more proper exercise and take other protective measures to maintain their bone mass." @default.
- W2348309819 created "2016-06-24" @default.
- W2348309819 creator A5055425558 @default.
- W2348309819 date "2013-01-01" @default.
- W2348309819 modified "2023-09-23" @default.
- W2348309819 title "Influential Factors of Osteoporosis with Multiple Sclerosis" @default.
- W2348309819 hasPublicationYear "2013" @default.
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