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- W2348331566 abstract "Objective To understand the genetics mechanism of extensive drug resistant Klebsiella pneumoniae by analyzing its resistant elements in plasmid p JM45-1. Methods Whole genome sequencing for an extensive drug resistant K. pneumoniae strain w as performed by using high throughput Roche 454 platform,then the resistant elements in its plasmid p JM45-1 w ere analyzed,and the cluster analysis w as performed by using the sequences of the plasmids recorded by National Center of Biotechnology Information( NCBI) w ith Fast M inimum Evolution method. Results The length of plasmid p JM45-1 w as 317 156 bp. The encoding genes of transfer genes of conjuagal plasmids,resistant genes to antibiotics and heavy metal ions,virulence factors,transposons and insertion sequences w ere detected in plasmid p JM45-1. M oreover,plasmid p JM45-1 w as 99% identical to 45 995 bases in 94 281 bases of resistant plasmid R100(Genbank accession No. AP000342. 1),while 87% identical to 8322 bases in 99 159 bases of F plasmid( Genbank accession No. AP001918. 1). So plasmid p JM45-1 might be a chimeric plasmid. In addition,plasmid p JM45-1 and plasmids in other K. pneumoniae isolates w ere in the same cluster,w hile plasmid p JM45-1 and plasmids in other enterobacteria isolates w ere in the different cluster. Conclusion The resistant genes to antibiotics and heavy metal ions in plasmid p JM45-1 played a key role in the development of the extensive drug resistance of K. pneumoniae.Furthermore,plasmid p JM45-1 is a conjugative transfer plasmid,and resistance genes could be horizontally transferred among bacteria to cause the spread of drug-resistant strains." @default.
- W2348331566 created "2016-06-24" @default.
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- W2348331566 date "2015-01-01" @default.
- W2348331566 modified "2023-09-25" @default.
- W2348331566 title "Resistant elements in plasmid of extensive drug resistant Klebsiella pneumonia" @default.
- W2348331566 hasPublicationYear "2015" @default.
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