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- W2348336075 abstract "Objective To study the relation between the level of serum HBV-DNA and PreS1 and HBeAg and to evaluate the clinical significance of PreS1.Methods Thirty healthy controls and 272 patients with chronic hepatitis B never treated with anti-viral therapy were selected.Serum level of HBV-DNA was determined by real-time fluorescence quantity PCR.Serum PreS1 and HBeAg were determined by ELISA.Results Serum HBV-DNA,PreS1 and HBeAg of healthy controls were all negative.Among 150 patients with serum level of HBV-DNA10~3 copies/ml PreS1 of 81 patients(54.00%) was positive and HBeAg of 10 patients(6.67%) was positive.Among 44 patients with serum level of HBV-DNA 10~3-5 copies/ml PreS1 of 22 patients(50.00%) was positive and HBeAg of 16 patients(36.36%) was positive.Among 68 patients with serum level of HBV-DNA 10~5-8 copies/ml PreS1 of 59 patients(86.76%) was positive and HBeAg of 43 patients(63.24) was positive.Among 10 patients with serum level of HBV-DNA10~8 copies/ml PreS1 and HBeAg of all patients were positive.If the level of HBV-DNA 10~3 copies/ml was suggested as cut-off value,the sensitivities of PreS1 and HBeAg were 74.59% and 56.56%,specificities were 46.00% and 93.33%,positive predict values were 52.91% and 87.34%,negative predict values were 69.00% and 72.54%,accuracy rates were 58.82% and 76.84% respectively.Conclusion The positive rates of PreS1 and HBeAg ignificantly increase as the level of HBV-DNA rises.Although the sensitivity of PreS1 is higher than that of HBeAg the specificity,positive predict value,negative predict value and accuracy rate are all lower than that of HBeAg." @default.
- W2348336075 created "2016-06-24" @default.
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- W2348336075 date "2006-01-01" @default.
- W2348336075 modified "2023-09-25" @default.
- W2348336075 title "Study relation between the level of serum HBV-DNA and PreS1 and HBeAg" @default.
- W2348336075 hasPublicationYear "2006" @default.
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