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- W2348348548 abstract "Objectives:To investigate the clinical application value of the Down′s serum screening tests in the second trimester for the detection of the 21-trisomy syndrome in the fetus,and to analyze the effectiveness of the Down′s serological screening tests conducted by our laboratory. Methods:Venous blood were collected for pregnant women at 15-20+6 weeks of pregnancy for screening of Down′s interim triple,and those at high risk were further detected by the non-invasive prenatal screening tests or direct prenatal diagnosis. Pregnancy outcomes were followed up by telephone. Results:The serum screening for Down′s detected 379 high-risk cases of 21-trisomy,while the karyotype analysis of amniotic fluid cells of fetuses diagnosed seven cases of 21-trisomy,three cases of 18-trisomy,one case of 13-trisomy syndrome,one case of chimeras,and 3 cases with other chromosomal structural abnormalities. Follow-up results demonstrated that while compared with those at low risk,the rate of fetal malformations by the B-type ultrasonic diagnosis was significantly higher for the high-risk cases detected by the Down′s screening test. Conclusion:Down trimester serum screening tests showed clinical value in the detection of fetuses with the 21-trisomy or the B-type ultrasonic malformations. The false-positive rate of the 21-trisomy screening test in the second trimester in our laboratory was 6.5%(371/5686),with the detection rate of 62.5%(5/8)." @default.
- W2348348548 created "2016-06-24" @default.
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- W2348348548 date "2014-01-01" @default.
- W2348348548 modified "2023-09-22" @default.
- W2348348548 title "The effectiveness analysis of the serum screening test for the Down's syndrome in the second trimester in 5694 cases of single birth" @default.
- W2348348548 hasPublicationYear "2014" @default.
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