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- W2348360201 abstract "Objective:To investigate the expression of CD88 in hepatocellular carcinoma(HCC) and its clinical significance.Methods: The different expression of CD88 mRNA and protein levels in HCC and peritumoral tissues in 56 HCC patients were determined by qRT-PCR,immunohistochemistry and Western blot,respectively.The clinical significance of CD88 was further explored.Results: The CD88 mRNA expression was significantly higher in HCC tissues than that in the perfumoral tissues(0.056±0.014 vs.0.003±0.0004,P0.001).Further more,the expression of CD88 mRNA in HCC tissues was higher in HCC patients with tumor size over 5 cm(0.1119±0.0339 vs.0.0256±0.0094),with tumor thrombus(0.0907±0.0271 vs.0.0245±0.009),and with TNM stage Ⅲ~Ⅳ(0.0876±0.02630 vs.0.0253±0.0096)(all P0.05).Immunohistochemistry results showed that CD88 positive rates in liver cancer and its adjacent tissues were 55.3% vs.37.5%(P0.05),Western blot results also showed that expression of CD88 in tumor tissue was higher than in adjacent noncancerous tissues(3.71 ±0.92 vs.0.91 ±0.34,P0.01).Conclusions: The over-expression of CD88 is associated with HCC malignant phenotype;CD88 may play an important role in HCC invasion and metastasis." @default.
- W2348360201 created "2016-06-24" @default.
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- W2348360201 date "2010-01-01" @default.
- W2348360201 modified "2023-09-22" @default.
- W2348360201 title "The Expression of CD88 in Hepatocellular Carcinoma and Its Clinical Significance" @default.
- W2348360201 hasPublicationYear "2010" @default.
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