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- W2348361341 abstract "Objective To study the protective effects and mechanisms of pharmacological postconditioning with Shenfu injection (SF) on ischemia-reperfusion (I/R) lung injury in rats. Methods Forty SD rats were randomly assigned to Sham operation group (group S), ischemia-reperfusion group (group I/R), I/R treated with SF postconditioning group (group SF/IPO) and ischemic postconditioning (group IPO), based on the established pulmonary in situ I/R model. The histological changes in lung tissues were examined following measurement of the ratio of wet to dry weight (W/D). The content of malondialdehyde (MDA) and superoxide dismutase (SOD) activity in lung tissues was assayed. Results Compared with group S, group I/R was characterized by marked pathologic changes, significantly increased W/D ratio, reduced SOD activity yet elevated concentration of MDA in the lung tissues (all P0.01). When compared with group I/R, the attenuated pathologic changes, reduced W/D ratio, increased SOD activity yet decreased MDA concentration were most impressive in group SF/IPO (all P0.01), followed by group IPO (all P0.01). Conclusion Pharmacological postconditioning with SF may effectively protect the rats from ischemia-reperfusion lung injury and may be a preferable approach for clinical application as compared with conventional methods." @default.
- W2348361341 created "2016-06-24" @default.
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- W2348361341 date "2013-01-01" @default.
- W2348361341 modified "2023-09-23" @default.
- W2348361341 title "Postconditioning with shenfu injection protects against pulmonary ischemia/reperfusion injury in rats" @default.
- W2348361341 hasPublicationYear "2013" @default.
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