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- W2348367042 abstract "The theory that the energy of cardiac contraction(cardiac work) is a function of the length of the muscle fiber(the end-diastolic volume,EDV) has been known as the Frank-Starling law of the heart(FSLH),which is reputed as the classic mechanism in physiology of the heart.The FSLH is discussed from various perspectives in this paper.First of all,this paper analyzed the difference between both of Frank's experiments of the stretch of isolated cardiac muscle and Starling's heart-lung preparation and the animal physiological practice,and focused on the Frank-Starling phenomenon(FSP) in the experiments,in which the increase in the preloads of the cardiac muscle enhances the contractility.The paper concludes that:(1) under normal physiological condition,from the outside of the heart,there is no such power that the potential energy of the venous blood was controlled in Starling and his associates' experiments,in which the artificial increase in the filling pressure caused the increase in the EDV;(2) the artificial increase of the preloads in the experiments,as far as the work of cardiac muscle contraction concerned,can certainly change the external environmental condition during contraction;(3) the FSP shown/provoked in the experiments is a response to adapt to the changes in the external environmental condition during contraction;(4) the response of the increase in the contractility to the increase of the preload has to undergo a train of mechanisms of excitation-contraction and chemical-mechanic coupling(changing factors) within myocardial cells;(5) therefore on the basis of the FSP in the experiments,people have concluded that the preload(one of the external environmental condition during contraction) may regulate and determine the cardiac work,which does not logically agree with the basics of scientific epistemology,viz.all the FSPs observed in the experiments do not provide enough evidence to support the FSLH.Then,the authors quote the biophysical formula of cardiac work Stroke work = P ×(EDV-ESV) which has been universally adopted to prove that there is no functional relation between the cardiac work and the EDV.According to the heart working's basic principle of biomathcmatsics and medical physics,the authors hold that the FSLH is a failure as a law to express the heart working." @default.
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- W2348367042 date "2009-01-01" @default.
- W2348367042 modified "2023-09-23" @default.
- W2348367042 title "Doubts about the Frank-Starling Law of Heart" @default.
- W2348367042 hasPublicationYear "2009" @default.
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