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- W2348371509 abstract "AIM To study the effects and mechanisms of chloride channel blockers (NFA and NPPB) on the contraction of isolated tracheal strips of guinea pigs. METHODSThe incubated isolated tracheal strips of guinea pigs were prepared. Various drugs were added respectively. KCl or 5 HT induced contractile effects and changes in KCl or 5 HT caused by chloride channel blockers and verapamil (Ver) were determined. RESULTS The contractions induced by KCl or 5 HT in isolated tracheal strips of guinea Pig were markedly inhibited by NFA and NPPB. The depressed percentage were 100 percent and 30 percent, repectively. The inhibitory effect of Ver was intermidiate between the effects of NFA and NPPB. NFA, NPPB and Ver markedly inhibited the contractions induced by Ca 2+ released from an intracellular store and extracellular Ca 2+ . CONCLUSION NFA and NPPB can significantly inhibit contraction of tracheal strips induced by KCl and 5 HT and their mechanism may be that blocking chloride channel can affect transportation of Ca 2+ ." @default.
- W2348371509 created "2016-06-24" @default.
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- W2348371509 date "2002-01-01" @default.
- W2348371509 modified "2023-09-25" @default.
- W2348371509 title "Effects of chloride-channel blockers on the contraction of isolated tracheal strip of guinea pigs" @default.
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