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- W2348383506 abstract "Objective To study the therapeutical effects of Ulinastatin(UTI) on fulminant hepatic failure(FHF) in Wistar rat and to investigate its underlying mechanism.Methods Seventy-two Wistar rats were randomly divided into three groups as normal group,model group and treatment group.The model group and trentment group rats were induced into FHF model by D-galactosamine(D-GalN) and lipopolysaccharide(LPS) intraperitoneal injection,while normal group rats were injected with equal volume normal sodium (NS).After model builded,treatment group rats were intraperitoneally injected with Ulinastatin 2×105 U/kg,while normal group and model group rats were injected with equal volume NS.At each point in time of 6,12,24,48 h,6 rats were put to death in each group.Plasma ALT,AST etc.were tested,and the mortality,hepatic tissue histology as well as myeloperoxidase(MPO) activity,plasma levels of TNF-α,IL-1β,IL-6,NO were determined.Results Compared with model group,survival rate of treatment group rats rose,plasma ALT,AST decreased,hepatic pathological damage alleviated,and MPO released,and plasma TNF-α,IL-1β,IL-6,NO dilivery reduced obviously. Conclusion The Ulinastatin has definite therapeutical effects on LPS/D-GalN-induced FHF in rat,including reducing proinflammatory factor,alleviating inflammatory cell infiltration." @default.
- W2348383506 created "2016-06-24" @default.
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- W2348383506 date "2009-01-01" @default.
- W2348383506 modified "2023-10-06" @default.
- W2348383506 title "The therapeutical effect of Ulinastatin on fulminant hepatic failure in Wistar rat" @default.
- W2348383506 hasPublicationYear "2009" @default.
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