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- W2348386912 abstract "Objective To study the regularities and the influencing factors of marrow stem cell mobilization after off-pump coronary artery bypass graft(CABG).Methods Seventy-five patiouts with coronary artery disease without acute myocardial infarction who needed selective CABG were included in this study.4 ml of blood samples were taken at 30 min pre-operation,6 h,12 h,24 h,48 h,72 h,and 120 h post-operation.The marrow stem cell counts were made by flow cytometer with CD34 and CD45 double antibody.The serum myocardium enzyme and troponin T were measured at the same time.Results There were a few marrow stem cells accounting for(1.32±1.16)‰ of all nucleated cells in the peripheral blood circulation in patients with coronary artery diseases before operation.The marrow stem cell counts significantly increased,peaking at 24 hours after off-pump CABG,accounting for(341± 2.00)‰ of all nucleated cells and returning to pre-operation level at 72-120 hours after operation in the peripheral blood circulation.Hyperlipidemia and diabetes mellitus had little effect on marrow stem cell mobilization,which was obviously reduced by hypertension.The marrow stem cells counts were positively correlated with CK,CK-MB,LDH,troponin T(r=0.70,P=0.00,r=0.66,P=0.00,r=0.48,P=0.00,r=0.75,P=0.00,respectively).Conclusions The marrow stem cells mobilize rapidly and temporarily after off-pump CABG.The extent of myocardial injury and coronary artery risk factors take part in marrow stem cell mobilization." @default.
- W2348386912 created "2016-06-24" @default.
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- W2348386912 date "2008-01-01" @default.
- W2348386912 modified "2023-09-25" @default.
- W2348386912 title "Clinical experiments on marrow stem cell mobilization after off-pump coronary artery bypass graft" @default.
- W2348386912 hasPublicationYear "2008" @default.
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