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- W2348392112 abstract "Objective To study the relationship between common genetic markers and the prognosis for non-small cell lung cancer(NSCLC),carry out molecular staging at the basis of TNM staging and provide predictive individual treatment plan.Methods Retrieved PubMed,Ovid,Cochrane library online to look up clinic randomized controlled trial,systematic review,Meta-analysis on genetic markers related to prognosis of NSCLC.Results 83 primary articles and 266 related articles involving p53,K-ras,VEGF,Cyclin E,Survivin could be searched.The mutation rate of p53 was 45%-75%,the emerging of p53 gene mutation in NSCLC indicated poor prognosis,especially in stage I lung adenocarcinoma.The mutation rate of K-ras was 15%-50%,detecting K-ras gene mutation in all stage lung adenocarcinoma by PCR indicated poor prognosis.The expression rate of VEGF was 66%-72%,VEGF was a poor prognosis factor for NSCLC.The expression rate of Survivin was 40%-85%,Survivin expressed in NSCLC from stage I to stage ⅢA showed poor prognosis,especially in squamous cell lung carcinoma.The expression rate of Cyclin E was 41%-53%,high expression of Cyclin E in NSCLC was related with poor prognosis,especially squamous cell lung carcinoma from stage I to stage Ⅱ.Conclusions p53,K-ras,VEGF,survivin and Cyclin E were composed to a molecular staging model to carry out molecular staging,which was feasible." @default.
- W2348392112 created "2016-06-24" @default.
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- W2348392112 date "2012-01-01" @default.
- W2348392112 modified "2023-09-24" @default.
- W2348392112 title "The Evidence-Based Medicine study of molecular staging for non-small cell lung cancer" @default.
- W2348392112 hasPublicationYear "2012" @default.
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