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- W2348396546 abstract "Objective To investigate the change of prostaglandin D2 receptor(DP1/CRTH2)on eosinophil(EOS)in exacerbation and remission phase patients with bronchial asthma(asthma).Methods Randomized case control clinical trial was designed.Thirty patients were randomly divided into two groups:exacerbation phase group 18 cases(4.7±3.8)years,and remission phase group(3.9±3.1)years,normal control was 24 cases(5.8±2.7)years.Radiological binding assay was used to study the DP1/CRTH2 receptors on EOS in peripheral blood.Results The EOS counts in exacerbation phase group were significantly higher than those in remission phase group and normal controls(×106/L)(exacerbation phase group,297±58,remission phase group 157±34 normal controls 95±26)(P0.01).The combining capacity of CRTH2 and the total combining capacity on EOS in exacerbation phase group were significantly higher than those in remission phase group and normal controls(fmol/106cell)(245.58±48.27 vs 154.13±67.25,119.29±53.47 and 456.14±25.57,337.51±38.52,301.22±39.54)(P0.01).Conclusions The combining capacity of CRTH 2 on EOS in exacerbation phase group are significantly higher,this imply that PGD2 mediates the chemotaxis of EOS will be via CRTH2 receptor." @default.
- W2348396546 created "2016-06-24" @default.
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- W2348396546 date "2009-01-01" @default.
- W2348396546 modified "2023-09-24" @default.
- W2348396546 title "Change of prostaglandin D_2 receptor on eosinophils in peripheral blood in bronchial asthma" @default.
- W2348396546 hasPublicationYear "2009" @default.
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