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- W2348406933 abstract "Objective To explore the possibility of pharmacodynamic monitoring of cyclosporine immuno-suppression by measuring T-cell functions in peripheral whole blood.Methods Different concentrations of CsA(0,10,50,100,200 nmol/L) were added to peripheral whole blood from five normal human volunteers.After concanavalin-A stimulation and culture,the whole blood samples were analyzed by flow cytometry detecting T-cell surface antigen markers(CD25,CD28,CD54) and the expression of intracellular IL-2.Data analysis was performed by software SPSS 13.0.Results We found that the percent of T-cell expressing CD25 or CD54 decreased in a CsA dose-dependent manner,and the percent of T-cell expressing IL-2 or CD28 did not.The coefficients of determination(r2) between the magnitude of drug concentrations and the magnitude of induction in percent of T-cell expressing CD25,CD54,CD28 or IL-2 were 0.901,0.949,0.162 and 0.425,respectively.We also found that there were considerable differences in the responses to CsA between individuals,regardless of the CsA dosage.Conclusion The results suggest that immunosuppression of CsA may be appropriately monitored by measuring T-cell function in peripheral whole blood,and the assay could promote efficacy and safety of CsA in clinics." @default.
- W2348406933 created "2016-06-24" @default.
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- W2348406933 date "2008-01-01" @default.
- W2348406933 modified "2023-09-23" @default.
- W2348406933 title "Pharmacodynamic monitoring of the immunosuppressive effects of cyclosporine" @default.
- W2348406933 hasPublicationYear "2008" @default.
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