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- W2348414862 abstract "Objective: To investigate the anti-rotavirus effects of Psidium Guajava Leaves,so as to provide an experimental basis for searching a new efficacious drug for treatment of rotavirus-caused diarrhea.Methods: The flavonoids and water decoction were extracted from Psidium Guajava Leaves,and added into MA104 cells.Afterwards,the cell viability was detected by methyl thiazolyl tetrazolium(MTT) assay,and median toxic concentration(TC50) was calculated.Then different concentrations of the two components,which was less than TC50,were added into rotavirus infected cells to determine their anti-rotavirus effects in vitro.Results: Both water decoction and flavonoids from Psidium Guajava Leaves had preventive effects against infection by rotavirus.For prophylactic use,the therapeutic index(TI)was 4.65 and 1.83,respectively.Meanwhile,the two components had therapeutic effects on rotavirus infected MA104 cells.The TI for treatment of rotavirus infection was 2.97 and 3.07,respectively.The virus inhibition ratio for prophylactic and treatment use significantly increased with the drug concentration increasing,showing a dose-dependent manner.Conclusion: The flavonoids and flavonoids from Psidium Guajava Leaves have strong anti-rotavirus effects in vitro." @default.
- W2348414862 created "2016-06-24" @default.
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- W2348414862 date "2009-01-01" @default.
- W2348414862 modified "2023-09-23" @default.
- W2348414862 title "Anti-rotavirus Effects of Water Decoction and Flavonoids from Psidium Guajava Leaves" @default.
- W2348414862 hasPublicationYear "2009" @default.
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