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- W2348455538 abstract "OBJECTIVE: To investigate the relationship of vascular endothelial growth factor receptor(Flt-1),platelet-derived growth factor receptor(PDGFR),basic fibroblast growth factor receptor(bFGFR) and angiogenesis to the biological behavior of gastric carcinoma(GC).METHODS: Seventy-one cases of GC,and 39 cases of normal gastric tissues were examined by using immunohistochemistry for the expression of angiogenic factor receptor and microvessel density(MVD).RETULTS: The positive rates of Flt-1,PDGFR and bFGFR in GC tissues were 53.5%,49.3% and 50.7% respectively,and were significantly higher than that in patients with normal tissues(12.8%,10.3%,7.7%,χ2 were 17.514,16.765 and 20.350,P=0.000).The high positive expression of three receptors in GC group was significantly correlated with TNM stage,regional invasion,lymphatic and blood stream metastasis(P0.01 or P0.05).But there were no correlation with the tumor size,histology type and differentiation degree.The MVD counts in GC and normal tissues were 45.2±15.2 and 28.6±4.2 respectively(t=5.083,P=0.001),the high positive expression of MVD had correlation with TNM stage,regional invasion and lymphatic and blood stream metastasis in GC(P0.01).There were significant correlation among the expression of Flt-1,PDGFR and bFGFR(P0.01).The incidence rates of lymph mode metastasis and blood metastasis with all three angiogenic factor receptors positively expressed,or all three negatively expressed were 91.7% and 68.2%,58.3% and 18.2%,respectively(χ2=7.769,P=0.005).The MVD counts in GC tissues were 60.5±18.0,40.4±5.1(t=21.38,P=0.001).CONCLUSIONS: The expression of three angiogenesis factor receptors and MVD might be significantly correlation with growth,invasion and metastasis of GC.The three receptors together may play a coordinated role in metastasis and invasion." @default.
- W2348455538 created "2016-06-24" @default.
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- W2348455538 date "2013-01-01" @default.
- W2348455538 modified "2023-09-25" @default.
- W2348455538 title "Expressions of Flt-1,PDGFR,bFGFR and MVD in gastric tissues and their relationship" @default.
- W2348455538 hasPublicationYear "2013" @default.
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