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• W2348515999 abstract "The proper localization and synthesis of postsynaptic glutamate receptors are essential for synaptic plasticity. Synaptic translation initiation is thought to occur via the target of rapamycin (TOR) and mitogen-activated protein kinase signal-integrating kinase (Mnk) signaling pathways, which is downstream of extracellular-regulated kinase (ERK). We used the model glutamatergic synapse, the Drosophila neuromuscular junction, to better understand the roles of the Mnk and TOR signaling pathways in synapse development. These synapses contain non-NMDA receptors that are most similar to AMPA receptors. Our data show that Lk6, the Drosophila homolog of Mnk1 and Mnk2, is required in either presynaptic neurons or postsynaptic muscle for the proper localization of the GluRIIA glutamate receptor subunit. Lk6 may signal through eukaryotic initiation factor (eIF) 4E to regulate the synaptic levels of GluRIIA as either interfering with eIF4E binding to eIF4G or expression of a nonphosphorylatable isoform of eIF4E resulted in a significant reduction in GluRIIA at the synapse. We also find that Lk6 and TOR may independently regulate synaptic levels of GluRIIA." @default.
• W2348515999 created "2016-06-24" @default.
• W2348515999 creator A5026901478 @default.
• W2348515999 creator A5027147155 @default.
• W2348515999 creator A5046735208 @default.
• W2348515999 creator A5068366061 @default.
• W2348515999 date "2016-01-01" @default.
• W2348515999 modified "2023-09-26" @default.
• W2348515999 title "The Extracellular-Regulated Kinase Effector Lk6 is Required for Glutamate Receptor Localization at the Drosophila Neuromuscular Junction" @default.
• W2348515999 cites W1506710296 @default.
• W2348515999 cites W1510879979 @default.
• W2348515999 cites W1526832384 @default.
• W2348515999 cites W1541412172 @default.
• W2348515999 cites W1555945582 @default.
• W2348515999 cites W1558727857 @default.
• W2348515999 cites W1603693213 @default.
• W2348515999 cites W1917583919 @default.
• W2348515999 cites W1934152683 @default.
• W2348515999 cites W1955231649 @default.
• W2348515999 cites W1963723155 @default.
• W2348515999 cites W1965894414 @default.
• W2348515999 cites W1967039423 @default.
• W2348515999 cites W1969497469 @default.
• W2348515999 cites W1978698911 @default.
• W2348515999 cites W1979883968 @default.
• W2348515999 cites W1981284278 @default.
• W2348515999 cites W1983163493 @default.
• W2348515999 cites W1984988598 @default.
• W2348515999 cites W1986781282 @default.
• W2348515999 cites W1988607674 @default.
• W2348515999 cites W1990219082 @default.
• W2348515999 cites W1998285904 @default.
• W2348515999 cites W1999194056 @default.
• W2348515999 cites W2002226709 @default.
• W2348515999 cites W2002378374 @default.
• W2348515999 cites W2004498315 @default.
• W2348515999 cites W2005176113 @default.
• W2348515999 cites W2005935748 @default.
• W2348515999 cites W2006257238 @default.
• W2348515999 cites W2006923532 @default.
• W2348515999 cites W2007597852 @default.
• W2348515999 cites W2008669399 @default.
• W2348515999 cites W2009138589 @default.
• W2348515999 cites W2010807686 @default.
• W2348515999 cites W2012065772 @default.
• W2348515999 cites W2014040647 @default.
• W2348515999 cites W2014904526 @default.
• W2348515999 cites W2015426350 @default.
• W2348515999 cites W2024878957 @default.
• W2348515999 cites W2026541961 @default.
• W2348515999 cites W2028036106 @default.
• W2348515999 cites W2030554076 @default.
• W2348515999 cites W2032666422 @default.
• W2348515999 cites W2035521247 @default.
• W2348515999 cites W2037191120 @default.
• W2348515999 cites W2038098576 @default.
• W2348515999 cites W2038860789 @default.
• W2348515999 cites W2039424996 @default.
• W2348515999 cites W2041303725 @default.
• W2348515999 cites W2042360183 @default.
• W2348515999 cites W2043685409 @default.
• W2348515999 cites W2044675465 @default.
• W2348515999 cites W2047999313 @default.
• W2348515999 cites W2049731104 @default.
• W2348515999 cites W2050733310 @default.
• W2348515999 cites W2050998615 @default.
• W2348515999 cites W2053050328 @default.
• W2348515999 cites W2053116732 @default.
• W2348515999 cites W2053304186 @default.
• W2348515999 cites W2055248589 @default.
• W2348515999 cites W2056994440 @default.
• W2348515999 cites W2058805971 @default.
• W2348515999 cites W2060630008 @default.
• W2348515999 cites W2060936720 @default.
• W2348515999 cites W2065178022 @default.
• W2348515999 cites W2065197926 @default.
• W2348515999 cites W2065613854 @default.
• W2348515999 cites W2074056212 @default.
• W2348515999 cites W2075817104 @default.
• W2348515999 cites W2076087951 @default.
• W2348515999 cites W2081787892 @default.
• W2348515999 cites W2081833699 @default.
• W2348515999 cites W2081927372 @default.
• W2348515999 cites W2082920258 @default.
• W2348515999 cites W2087448029 @default.
• W2348515999 cites W2088485943 @default.
• W2348515999 cites W2091983756 @default.
• W2348515999 cites W2092086723 @default.
• W2348515999 cites W2094975095 @default.
• W2348515999 cites W2098912234 @default.
• W2348515999 cites W2100135144 @default.
• W2348515999 cites W2100155309 @default.
• W2348515999 cites W2100344731 @default.
• W2348515999 cites W2102548112 @default.
• W2348515999 cites W2102889876 @default.
• W2348515999 cites W2107660867 @default.
• W2348515999 cites W2110643873 @default.
• W2348515999 cites W2113068318 @default.
• W2348515999 cites W2116966832 @default.
• W2348515999 cites W2129307474 @default.

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