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- W2348535119 abstract "Aim:To investigate All Trans Retinoid Acid (ATRA) phosphorylation of JNK and induction of apoptosis in human retinoblastoma Y79 cells. Methods:Antiproliferation effects of ATRA on Y79 cells were determined by 3H thymidine incorporation. Cell cycle analysis was performed by flow cytometry, JNK phosphorylation was analyzed by Western blot analysis. Results:After 36 h treatment with 10 -7 mol·L -1 ATRA, 3 H thymidine incorporation decreased in Y79 cells, and the effects was time and dose dependent Y79 cells were arrested in G 0/G 1 and Sub G 1 peak appeared after 36h treatment with ATRA. Curcumin,a JNK blocker, blocked ATRA inhibition of cell growth. JNK was phosphorylated in 10 to 30 min after treatment. Conclusion:ATRA could inhibit cell growth and arrest the cells in G 0/G 1,JNK phosphorylating mediated ATRA's effects in Y79 cells. ATRA might have clinical application for treatment of retinoblastoma" @default.
- W2348535119 created "2016-06-24" @default.
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- W2348535119 date "2002-01-01" @default.
- W2348535119 modified "2023-09-28" @default.
- W2348535119 title "Phosphorylation JNK Mediated All Trans Retinoid Acid Inhibition of Human Retinoblastoma Cells Growth in Y79 Cells" @default.
- W2348535119 hasPublicationYear "2002" @default.
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