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- W2348547177 abstract "Objective: To study the effect of Yin-qiao-jie-du pill on β-defensin1's expression in the lung tissue of mice infected with influenza virus,and to investigate its antiviral effect from antibacterial peptide perspective.Methods:Mice infected with influenza virus A adapted strains of rat lung(FM1) were selected as animal model.The infected mice were dosed daily by gastric gavage with Yin-qiao-jie-du pill.Expression of β-defensin1 in the lung tissue of mice was detected with real-time quantitative PCR after being infected for 1day,3 days,and 7 days.Results: The level of β-defensin1 mRNA expression in the lung tissue of mice after being infected for 1day and 3 days was higher,compared with that of model group.The gene expression level was lower after being infected for 7 days.There was a significant difference between the expression level of the lung tissue of mice in being infected for 3 days group and model group(P0.01).From 1st to 8th day after infection,the gene expression showed increasing firstly and then decreasing trend,and on the 4th day after infection in the peak.Conclusion:Yin-qiao-jie-du pill can increase β-defensin1 mRNA expression in lung tissue of mice that infected with influenza virus A in early stage." @default.
- W2348547177 created "2016-06-24" @default.
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- W2348547177 date "2013-01-01" @default.
- W2348547177 modified "2023-09-28" @default.
- W2348547177 title "Effect of Yin-Qiao-Jie-Du Pill on β-defensin1's Expression in Lung Tissue of Mice Infected With Influenza A Virus" @default.
- W2348547177 hasPublicationYear "2013" @default.
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