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- W2348566805 abstract "Objective To study the therapeutic effect of transplanted bone marrow mononuclear cells(BMMNC)on middle cerebral artery(MCA)embolism and their differentiation in brain of ischemic stroke mice.Methods Forty-one male Kunming mice were included in this study.A MCA embolism model was established by Longa occlusion.Thirty-four mice in the established model were randomly divided into vehicle group and BMMNC transplantation group(17in each group).Nerve injury was assessed according to their mNSS score on days 1,3,7,14,28,respectively.Differentiation of BMMNC in brain of mice was observed with double immunofluorescence staining.Results The mNSS score was significantly lower in BMMNC group than in vehicle group at different time points(12.54±1.50 vs 13.02±1.52,9.52±1.25 vs 11.17±1.05,7.92±1.24 vs 10.75±1.06,5.82±1.23 vs 7.93±1.23,4.92±1.25 vs 6.83±1.12,P0.05).Brdu and GFAP double positive cells were detected in infracted cortex and hippocamal dentate gyrus of BMMNC group.Conclution Transplanted BMMNC can differentiate into astrocytes and effectively improve the neurological function in ischemic stroke mice." @default.
- W2348566805 created "2016-06-24" @default.
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- W2348566805 date "2014-01-01" @default.
- W2348566805 modified "2023-09-24" @default.
- W2348566805 title "Differentiation of transplanted bone marrow mononuclear cells into astrocytes in brain of ischemic stroke mice" @default.
- W2348566805 hasPublicationYear "2014" @default.
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