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- W2348576529 abstract "Objective To investigate the expression and significance of Pim-3 and Cdk-2 in lung squamous cell carcinoma.Methods The expression of Pim-3 and Cdk-2 in lung squamous cell carcinoma was detected by immunohistochemistry and its correlation with clinical-pathological factors was statistically analyzed.Results The expression of Pim-3 and Cdk-2 protein was significantly increased in lung squamous cell carcinoma than that of non-cancerous lung tissues(P0.001).The expression of Pim-3 was correlated with the degree of carcinoma differentiation,and its level in high and moderate differentiation group was much lower than the poor differentiation group(P0.01).No correlation was found between the expression level of Pim-3 and Cdk-2 and the gender,size,age,history of smoking(P0.05).There was statistical difference between Lymph node metastasis group and no-Lymph node metastasis group(P0.001).The expression of Cdk-2 was correlated with the pathological TNM stage(P0.05),and its level in stage Ⅰ and Ⅱ was higher than stage Ⅲ and Ⅳ(P0.05).There were positive correlation between the expression of Pim-3 and Cdk-2(P=0.001).Conclusion High expression of Pim-3 and Cdk-2 protein may be closely related to the occurrence and development of lung squamous cell carcinoma." @default.
- W2348576529 created "2016-06-24" @default.
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- W2348576529 date "2012-01-01" @default.
- W2348576529 modified "2023-09-24" @default.
- W2348576529 title "Significance of Pim-3 and Cdk-2 Expression in Lung Squamous Cell Carcinoma" @default.
- W2348576529 hasPublicationYear "2012" @default.
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