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- W2348589296 abstract "Objective To explore the carcinogenicity of 308nm excimer light long-term irradiating with therapeutic dose to the skin of mice.Methods A total of 96 Kunming mice were divided into six groups randomly by different irrndinted time of 308 nm excimer light,as 4-weeks irradiated group,8-weeks irradiated group,12-weeks irradiated group,16-weeks irradiated group,20-weeks irradiated group and 24-weeks irradiated group.Normal control for each group were established.The incipient dose was 60mJ/cm2.Irradiated once a week,and increased the dose gradually depending on the response.After finishing irradiations,the expression of P53 protein was detected by HE staining and immunochemical method.Results In normal control groups,The pathology of cutaneous tissue had no changes,and the positive expression of P53 protein was time-independent(P0.05).But in irradiated groups,atypical hyperplasia and squamous cell carcinoma were observed after 16-weeks excimer light irradiation.The positive expression of P53 protein in irradiated groups was increased gradually accompany with irradiation time extending(P0.05).There were significant difference among 16-weeks groups,20-weeks groups and 24-weeks groups(all P0.05),and the positive expression rate of P53 protein in excimer light irradiated groups was higher than that in control groups.Conclusion 308nm excimer light irradiating to the skin of mice has carcinogenicity.The longer irradiation time is,the greater the risk of cancer is." @default.
- W2348589296 created "2016-06-24" @default.
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- W2348589296 date "2012-01-01" @default.
- W2348589296 modified "2023-09-24" @default.
- W2348589296 title "The Carcinogenicity of 308nm Excimer Light Irradiating to the Skin of Mice with Therapeutic Dose" @default.
- W2348589296 hasPublicationYear "2012" @default.
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