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- W2348591084 abstract "Objective To evaluate the effects of soy isoflavones(SI) on male reproductive regulation in Black Small-eared pigs.Method Fifty male black small-eared pigs were randomly divided into control group(fed a test diet),low,medium and high doses of SI group and diethylstilbestrol group.Three different doses of SI(125 mg / kg,250 mg / kg,and 500 mg / kg) and 0.5 mg/kg diethylstilbestrol were evenly mixed in the feed and fed to pigs for 60 d(The purity of SI 80%).The levels of GnRH,LH,FSH,Tes and E2 were analyzed by radioimmunoassay,and testis and epididymis were weighed.The mRNA expression of P450scc,3β-HSD and StAR in testicular tissue,which were associated with testosterone synthesis,was measured by RT-PCR.Results In 250 mg/kg SI group,testicular index increased by 44.76%(P0.05);and serum testosterone level increased by 51.49% than the control group(P0.05).The mRNA expression of StAR was up to 1.43%,significantly different to control group(P0.05).In 500 mg/kg SI group,the testicular index decreased by 39.92%(P0.05).and serum testosterone level decreased by 53.69﹪ than the control group(P0.05).The mRNA expression of StAR was 0.49%,significantly different to 250 mg/kg SI group(P0.05).Conclusion Soy isoflavones can affect the male reproductive hormone secretion,the growth and development of testis and epididymis,enzyme activity of testosterone synthesis,and expression of reproductive hormones' gene in the brain,and in dosage-dependant ways.[ACTA NUTRIMENTA SINICA,2011,33(6):584-588]" @default.
- W2348591084 created "2016-06-24" @default.
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- W2348591084 date "2011-01-01" @default.
- W2348591084 modified "2023-09-25" @default.
- W2348591084 title "EFFECTS OF SOY ISOFLAVONES ON THE MALE REPRODUCTIVE REGULATION IN BLACK SMALL-EARED PIGS" @default.
- W2348591084 hasPublicationYear "2011" @default.
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