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- W2348606670 abstract "Objective:To study the effects of hyperbaric oxygen and its relationship with ICAM-1 on myocardial ischemia and reperfusion injury of rabbits. Method: Fifty-six family rabbits were allocated to control group, IR group and HBO randomly. Animals experienced LDA occlusion for 60 minutes ischemia and following reperfusion for 120 minutes. Animals in group HBO received hyperbaric oxygen infusion before ischemia and during reperfusion. The myocardial ischemia were taken from all the rabbits separately, ICAM-1 were detected with immunohistochemtry, the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA)in homogenate were detected, the infarct size was caculated as well. Results: The activity of SOD was lower in group IR and and group HBO than that in control(P0.05), while the quantity of MDA is higher( P 0.05). Myocardial infarction area was smaller in group HBO than that in group IR(P 0.05). The expression of ICAM-1 was significantly up-regulated in group IR. Conclusion:Hyperbaric oxygen treatment down-regulates the expression of ICAM-1 and increases the activity of SOD, thereby reducing the infarction area in myocardial ischemia and reperfusion injury of rabbits." @default.
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- W2348606670 date "2009-01-01" @default.
- W2348606670 modified "2023-09-22" @default.
- W2348606670 title "Effects of hyperbaric oxygen on the protective function after myocardial ischemia and reperfusion injury and its relationship with ICAM-1" @default.
- W2348606670 hasPublicationYear "2009" @default.
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