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- W2348609035 abstract "AIM To determine retinamidic acid and its isomer by reversed phase HPLC and to control the remains of reactants, tretinoin and p aminobenzoic acid, in retinomidic acid by normal phase HPLC. METHODS A reversed phase HPLC system consisting of an ODS column and a mixture of methanol 0 02 mol·L -1 sodium dihydrogen phosphate solution ( 82∶18 ) as the mobile phase was used. The flow rate was 1 0 mL·min -1 and detection was effected at 367 nm. A normal phase HPLC system including a CN column and a mixture of n hexane alcohol glacial acetic acid (100∶10∶0 3) as the mobile phase was used. The flow rate was 0 8 mL·min -1 and the wavelength of detection was 320 nm. RESULTS The assay of retinamidic acid displayed good linearity over the concentration range of 0 05～0 5 μg·μL -1 and the limit of detection was 3 ng in the reversed phase HPLC. The detecting limit of tretinoin was 5 ng with normal phase HPLC. Three lots of retinamidic acid samples were analyzed with the two HPLC methods. CONCLUSION Retinamidic acid and its isomers were separated perfectly. Tretinoin and p aminobenzoic acid were not detected in the samples. The reversed phase HPLC is simple, accurate and reproducible. It can be used to control the quality of retinamidic acid and its isomers. The normal phase HPLC is better in separating tretinoin and p aminobenzoic acid and may be used to control the impurity of reactants." @default.
- W2348609035 created "2016-06-24" @default.
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- W2348609035 date "2000-01-01" @default.
- W2348609035 modified "2023-09-22" @default.
- W2348609035 title "STUDY ON THE QUALITY OF RETINAMIDIC ACID" @default.
- W2348609035 hasPublicationYear "2000" @default.
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