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- W2348631303 abstract "Objective To investigate the changes of reactive oxygen species( ROS) level and mitochondrial fissionfusion in SH-SY5Y neurons with chronic fluorosis. Methods Neuroblastoma SH-SY5Y cells were exposed to different concentrations of fluoride( 0. 04 and 4 mmol /L) in vitro to build cellular model of fluorosis with the exposure time of 6,12,24,and 48 hours,respectively. Mitochondrial morphology and ROS levels of SH-SY5Y stained by mito-tracker RED probe and ROS fluorescence dyes were observed with fluorescence microscope. Results Compared with untreatment cells,the numbers of ROS stain positive SY-SY5Y cells( 0. 4 mmol /L fluoride: 15. 1 ± 1. 4,12. 8 ± 2. 5,22. 6 ± 2. 4,30. 0 ± 3. 1; 4 mmol /L fluoride: 32. 5 ± 1. 9,38. 1 ± 2. 2,69. 3 ± 3. 1,84. 3 ± 3. 5) and the numbers of abnormal mitochondria in morphology( 0. 4 mmol /L fluoride: 13 ± 1. 4,15 ± 1. 7,22. 9 ± 1. 9,23. 7 ± 1. 6; 4 mmol /L fluoride: 15. 2 ± 2. 3,23. 8 ± 1. 8,29. 1 ± 4,47. 7 ± 3. 3) were significantly increased after exposure of 6,12,24,and 48 hours( P 0. 05). Conclusion Taking excessive amount of fluoride results in high level of oxidative stress and mitochondrial fragmentation,which are dependent on the exposure time and dose of fluoride." @default.
- W2348631303 created "2016-06-24" @default.
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- W2348631303 date "2014-01-01" @default.
- W2348631303 modified "2023-09-23" @default.
- W2348631303 title "Changes of ROS level and mitochondria fission-fusion in SH-SY5Y cells with chronic fluorosis" @default.
- W2348631303 hasPublicationYear "2014" @default.
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