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- W2348632961 abstract "Objective To study the relationship between the expression of cyclooxygenase-2(COX-2) and the mismatch repair(MMR) genes in hereditary nonpolyposis colorectal cancer(HNPCC).Methods 20 patients with HNPCC from 19 pedigrees from May 2008 to October 2011 were selected,and 23 patients with sporadic colorectal cancer treated in our hospital in the same period were selected as the control group.The immunohistochemistry and PCR techniques were used to detect the COX-2 expression and MMR gene expression of the two groups.Results The high expression rate of COX-2 was 40.0% in HNPCC colorectal cancer and 91.3% in sporadic colorectal cancer,with statistically significant difference between the two groups(χ2 = 10.172,P 0.05).The expression loss rate of COX-2 was 70% in HNPCC colorectal cancer and 13% in sporadic colorectal cancer,with statistically significant difference between the two groups(χ2 = 9.872,P 0.05).The high expression rate of COX-2 was 21.4% and 66.7% in the hereditary colorectal cancer and the sporadic colorectal cancer with MMR expression loss respectively,which were significantly lower than the 83.3% and 95.0% in those with MMR positive expression,with statistically significant differences(χ2 = 7.357,5.039,P 0.05).Correlation analysis showed that the expression loss rate of MMR was positively correlated to the low expression rate of COX-2(r = 1.869,P 0.05) in the HNPCC colorectal cancer,and the expression rate of MMR was positively correlated to the high expression rate of COX-2(r = 1.176,P 0.05).Conclusion The HNPCC was lower than the sporadic colorectal cancer in the expression of COX-2,but higher in the expression rate of MMR gene.The expression of COX-2 and MMR gene are of important significance in the screening and pathogenesis of HNPCC." @default.
- W2348632961 created "2016-06-24" @default.
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- W2348632961 date "2012-01-01" @default.
- W2348632961 modified "2023-09-23" @default.
- W2348632961 title "Analysis of COX-2 expression and MMR gene expression in hereditary nonpolyposis colorectal cancer" @default.
- W2348632961 hasPublicationYear "2012" @default.
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