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- W2348651631 abstract "Objective To measure various coagulation markers such as prothrombin fragment F1+2(F1+2),thrombin/antithrombin complexes(TAT) and D-dimer,and evaluate the outcome of early diagnosis and management of pre-disseminated intravascular(coa)-gulations(pre-DIC) in high-risk neonates.Methods The high-risk group(96 cases) admitted to a NICU,which 30 pre-DIC neonates were subdivided and treated with heparin and tranexamic acid,and control group(36 normal neonates) were evaluated,for their(F1+2),TAT,D-dimer in peripheral blood.Results Levels of F1+2,TAT and D-dimer were increased in high-risk group.Compared with controls,concentrations of those markers had significant differences.Sensitivity of TAT was the highest,while F1+2 was the specifilest;Concertrations of F1+2,TAT,D-dimer in patients who received specific DIC therapy decreased significantly;F1+2 had significantly positive linear correlations with plasma TAT(r=0.70 P0.01),D-dimer(r=(0.42) P0.05),TAT also had a significantly positive linear correlations with plasma D-dimer(r=0.35 P0.05);The score showed negative linear correlations with plasma F1+2(r=-0.68 P0.01),TAT(r=-0.72 P0.01),D-dimer(r=-0.54 P0.01).Conclusions Early diagnosis and proper management of pre-DIC,before over bleeding,in high-risk patients admitted a NICU using combined F1+2,TAT,(D-dimer) assays have a positive impact on their prognosis." @default.
- W2348651631 created "2016-06-24" @default.
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- W2348651631 date "2006-01-01" @default.
- W2348651631 modified "2023-09-24" @default.
- W2348651631 title "Evaluation of Early Detection and Management of Pre-Disseminated Intravascular Coagulations in High-Risk Neonates" @default.
- W2348651631 hasPublicationYear "2006" @default.
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